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CYTOCHROME P-450 CYP11B2
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP11B2
Descriptor
Spanish
:
Citocromo P-450 CYP11B2
Descriptor
Portuguese
:
Citocromo P-450 CYP11B2
Synonyms
English
:
CYP11B2
Aldosterone Synthase
Steroid 18-Hydroxylase
Tree Number:
D08.244.453.915.050
D08.811.682.690.708.170.915.050
D08.811.682.690.708.783.050
D12.776.422.220.453.915.050
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of
steroids
in the presence of molecular
oxygen
and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of
CORTICOSTERONE
to
18-hydroxycorticosterone
and the subsequent conversion to
ALDOSTERONE.
Indexing Annotation
English
:
/antag: coordinate with
CYTOCHROME P-450 ENZYME INHIBITORS
History Note
English
:
2015 (1979)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33013
Unique Identifier:
D019405
Occurrence in VHL
:
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